Category 1: Irrelevant Games, such as NFC team vs. NFC team matchups or games featuring AFC non-threats (9)
Houston Texans (2 - 11) vs. Indianapolis Colts (8 - 5) - The Colts, despite their recent struggles, have clinched the AFC South. The Texans just fired their head coach, so I'd expect the team with something to play for (the Colts) to win.
Category 2 Games: AFC team vs. NFC team matchups (3)
Root for Detroit Lions to defeat the Baltimore Ravens (7 - 6) - The Ravens have a head-to-head tiebreak advantage over the Dolphins but lose on the conference tiebreak with a 6-4 AFC record (60% win percentage) versus the Dolphins' 6-3 AFC record (66.7% win percentage). Therefore, Ravens win a spot if there is a 2-way tie, but they probably lose to the Dolphins in the event of a 3-way tie. It's better to hope for the Ravens to lose than bank on an unlikely 3-way tie, so hopefully the Ravens start losing this week. Plus, this means we get to root for Megatron and Reggie Bush this week, so that should be fun.