Is it Wake and Misi? Is it Wake and Moses? Is it Alama-Francis and Wake? Who would you prefer to start at OLB against the Bills? Nolan may play certain players to get favorable matchups against the other team...dangerous receiving TE or better blocking TE and alot depends on how he plans to blitz.
Omar Kelly has Quentin Moses behind Wake at ROLB/WOLB and IAF starting over Misi but I realize that nothing has been set yet.
My preference would be to see Wake at WOLB and Moses at SOLB on first down and to start the game. Moses seems to be pretty good at setting the edge on the Strong side, in fact, that may be his greatest strength. Maybe use IAF and Moses on short yardage and use Wake and Misi on passing downs or longer yardage (2nd and 10). When Wake needs a breather, bring in Misi off the weak side and use IAF to back up Moses on the Strong side. On passing downs, we actually look pretty good against the pass from the base defense with linebackers Misi, Carpenter, Dansby, and Wake.